Features of vasoactive substance regulation in chorionic villi in women with spontaneous abortion and active cytomegalovirus infection

The aim of the study was to assess levels soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF), and vascular endothelial A (VEGF-A) in tissue extracts comparison with histologic examination endometrium chorionic villi women spontaneous abortion active cytomegalovirus (CMV) infection. Materials methods . 81 at 7–9 weeks pregnancy were examined: them, 51 CMVseropositive infection after abortion, 30 patients CMV-seronegative, healthy therapeutic abortion. Immunoglobulins (Ig) M G CMV IgG avidity measured blood plasma; sFlt1, PlGF, VEGF-A determined by enzyme immunoassay. DNA detected mononuclear cells peripheral blood, urine, real-time polymerase chain reaction (PCR). carried out. Results In villus infection, concentration sFlt1 3.25 times higher (p < 0.001), PlGF 1.31 0.001) 2.16 lower than women. strong negative correlation established between (r = –0.702; p –0.858; 0.0005), a positive revealed 0.860; 0.001). According data examination, lag decidual transformation uterine vessels, trophoblast invasion, differentiation villi, formation fetal circulation detected. Conclusion mechanisms include an imbalance pro- anti-angiogenic factors, which causes impaired development uteroplacental circulation.